AnNCR-SNP integrates data from various sources, allowing the user to investigate the potential effects of variants in non-coding regions of the human genome. AnNCR-SNP consists of a database containing data on all non-coding elements and two main programs: manager and finder. The manager program is responsible for creating the local data-base, and the finder program receives the user queries in order to search in the local database and retrieve information. The user can find information about various regu-latory elements, such as TFBs, open chromatin, histone modification and methyla-tion sites, information about SNPs from dbSNP and gene information from RefSeq.